We subsequently performed in silico analysis to predict piRNA-mRNA interactions. cruzi infection in primary human cardiac fibroblasts by RNA-Seq. In this study, we aim to evaluate dysregulation of a class of sncRNAs called piRNAs during early phase of T.
cruzi infection, particularly small noncoding RNAs, has yet to be elucidated. The role of regulatory gene expression machinery during T. Accumulating evidence suggests that the parasite induces alterations in host gene expression profiles in order to facilitate infection and pathogenesis. About 40% of infected individuals will develop cardiovascular, neurological, and/or gastrointestinal pathologies. Though originally endemic to Central and South America, globalization has led to increased parasite presence in most industrialized countries. Trypanosoma cruzi, the etiological agent of Chagas Disease, causes severe morbidity, mortality, and economic burden worldwide.
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